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The study by Cerrone et al. showed that exercise reduced the cardiac desmosomal function. This was well tolerated in healthy murine hearts, which had a ‘desmosomal reserve’, but was catastrophic for mice with PKP2 deficiency. One can hypothesize that the desmosomal reserve may be part of the explanation of why some athletes without a known genetic predisposition develop ARVC. ARVC, arrhythmogenic right ventricular cardiomyopathy; PKP2, plakophillin-2.
