Figure 1.

Organization of necrotic granulomas during mycobacterial infection. Necrotic granulomas are structured around a central core of necrotic cell debris in which much of the bacteria are concentrated. Layers of epithelioid macrophages surround the necrotic core interspersed with other macrophage populations. A diversity of other cell types are recruited to the granuloma and can be integrated into this structure at the periphery as well as within the epithelioid layers of the granuloma.