Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 7;13:783254. doi: 10.3389/fimmu.2022.783254

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhang, Tao, Chen, Zhao, Feng, Chen and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Anti-BAFF antibody decreased colon level of NLRP3 inflammasome in DSS-induced experimental chronic colitis in mice. (A–E) Total mRNA was extracted from colonic samples to determine the mRNA expression of NLRP3, AIM2, NLRP1, NLRC4 and NLRP6 by RT-qPCR. (F) Representative immunoblot bands for the NLRP3, ASC, cleaved-IL-1β and cleaved-caspase-1 proteins. GAPDH was used as a loading control. (G–J) Histogram of relative expression of NLRP3, ASC, cleaved-IL-1β and cleaved-caspase-1 (n = 6–9 per group). NLRP3, NOD-like receptor protein 3, AIM2, absent in melanoma 2, NLRP1, NLR family, pyrin domain containing 1, NLRC4/IPAF, IL-1β converting enzyme protease activating factor, NLRP6, NOD-like receptor family pyrin domain containing 6. ns, P > 0.05. Ctrl, CON.