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. 2022 Mar 7;13:783254. doi: 10.3389/fimmu.2022.783254

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Copyright © 2022 Zhang, Tao, Chen, Zhao, Feng, Chen and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-BAFF antibody inhibited NLRP3 inflammasome protein in RAW264.7 cells and bone derived macrophages (BMDMs). RAW264.7 cells and BMDMs were primed with LPS (1 ug/ml) for 6 h. Anti-BAFF antibody or mouse immunoglobulin G1 (IgG1) isotype control antibody at 500 ng/ml or 1 ug/ml in the presence of LPS 1 ug/ml for 6 h, then BMDMs pulsed with ATP (2 mM, Sigma-Aldrich, MO, USO) for 30 min. (A, B) Representative immunoblot bands for the NLRP3, ASC, cleaved-IL-1β, cleaved-caspase-1 proteins. GAPDH was used as a loading control. ns, P > 0.05.