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. 2022 Mar 7;13:858256. doi: 10.3389/fimmu.2022.858256

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Copyright © 2022 Lu, Sun, Xu, Saaoud, Shao, Drummer, Wu, Hu, Yu, Kunapuli, Bethea, Vazquez-Padron, Sun, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The 53.7% out of 21,306 human protein genes can be classified into six secretomes. (A) Six secretomes, canonical (with signal peptide), caspase-1 (secretome mediated via N-terminal gasdermin D protein-formed channel when caspase-1 is activated), caspase-4 (secretome mediated via N-terminal gasdermin D protein-formed protein channel when caspase-4 (humans)/caspase-11 (mice) is activated) and exosomes, are the large secretomes with > 900 proteins, Weibel-Palade bodies (WPB), and autophagy secretome. (B) Venn Diagram Analysis was used to classify all the secretory protein genes into the secretome-shared genes and secretome-specific genes in six secretomes, which are ranked from the highest specificity to the lowest as exosome (83%) > canonical (68%) > caspase-1 (56%) > caspase-4 (49%) > autophagy (37.5%) > WPB (8%).