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. 2022 Mar 7;13:858256. doi: 10.3389/fimmu.2022.858256

Figure 2.

Figure 2

The three major aortic diseases including atherosclerosis, chronic kidney disease (CKD), and abdominal aortic aneurysm (AAA) significantly modulate the expression of six secretomes in aortas (A–C), suggesting that aorta is a new immune and endocrine organ in pathologies. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in human endothelial cells and Angiotensin-II (Ang-II) treatment in vascular smooth muscle cells also modulate the expression of six secretomes (A–C), suggesting that in response to danger associated molecular pattern (DAMPs, Ang-II) pathogens-associated molecular pattern (PAMPs, MERS-CoV) major aortic cell types such as endothelial cells and vascular smooth muscle cells modulate the expression of six secretomes. (D) Atherosclerosis and chronic kidney disease modulate the expression of secretomic genes much more than abdominal aortic aneurysm. (E) Angiotensin-II upregulates the expression of secretomic genes much more than downregulating the expression of secretomic genes where MERS-CoV infection downregulates more than upregulates the expression of secretomic genes. P < 0.05 |LogFC|>1. LogFC>1 or < -1.