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. 2022 Mar 7;13:858256. doi: 10.3389/fimmu.2022.858256

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Copyright © 2022 Lu, Sun, Xu, Saaoud, Shao, Drummer, Wu, Hu, Yu, Kunapuli, Bethea, Vazquez-Padron, Sun, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elastase induced AAA aortas have more inflammatory/immune pathways than that of Ang-II induced AAA aortas. (A) The signal pathways of secretomic genes are different in AAA progression. P < 0.05, |LogFC|>1. (B) IPA analysis of elastase induced AAA (GSE51229) in each secretory pathway. Z score>1. (C) The Venn diagram of upregulated pathways in Day 7 Ang II induced AAA and elastase induced AAA. Z score>1 .