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. 2022 Mar 7;13:858256. doi: 10.3389/fimmu.2022.858256

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Copyright © 2022 Lu, Sun, Xu, Saaoud, Shao, Drummer, Wu, Hu, Yu, Kunapuli, Bethea, Vazquez-Padron, Sun, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Canonical secretome and caspase 1 secretome play more roles at early MERS-CoV (COVID-19 homoglous virus) infection of human microvascular endothelial cells whereas caspase 4 secretome and exosome secretome play more roles in the late and chronic phase infection; and these results have suggested novel therapeutic targets. (A) Canonical secretion and exosomes are most important secretory pathways in MERS condition. Number of differentially modulated genes in each pathway. P <0.05, |LogFC|>1. (B) MERS 36 hour is a transition time point in this process. Number of pathways which are regulated in MERS condition. (|Z score|>1 ). (C) Percentage of up/down gene number in each group based on (A). (D) Percentage of upregulated genes in each group. (E) Percentage of upregulated pathways in each group based on (B). (F) IPA analysis of upregulated genes in each group. Top 10 pathways are shown. Z score>1.