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. 2022 Mar 7;13:858256. doi: 10.3389/fimmu.2022.858256

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Copyright © 2022 Lu, Sun, Xu, Saaoud, Shao, Drummer, Wu, Hu, Yu, Kunapuli, Bethea, Vazquez-Padron, Sun, Jiang, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased trained immunity genes and decreased trained tolerance regulator immune-responsive gene 1 (IRG1) participate in upregulations of SGs in atherosclerotic, Ang-II induced AAA and CKD aortas, and MERS-CoV infected Ecs. (A) Model of trained immunity. (B) Trained immunity gene list from http://www.ieom-tm.com/tidb/browse. (After remove 17 duplicated gene by Excel, totally 101 genes involved) IPA analysis of 101 trained immunity genes. (C) Number of upregulated trained immunity gene in different time course disease and condition. P < 0.05, LogFC>1. (D) The LogFC of IRG1 in different time course and condition.(P < 0.05). (E) The expression of IL-1 family genes in different condition. IL-1 family genes from PMID: 34844039, P < 0.05, LogFC was showed in table. (F) Number of downregulated secretomic genes in HIF1a-/- (GSE29765), SET7 SiRNA (GSE53038) and mTOR inhibitor (GSE138558) condition. P < 0.05, LogFC>1. (G) Working model of trained immunity.