Table 1.
The most 89 top functional pathways carried out by five secretomes are secretome-specific and are not shared by other secretomes, suggesting that five secretomic mechanisms have different functions.
| Table 1A | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Canonical | Canonical | Canonical | Canonical | Canonical | Caspase1 | Caspase1 | Caspase1 | Caspase4 | Caspase4 | Exosomes | Exosome | |
| Specific | Caspase1 | Caspase4 | Exosomes | WPB | Specific | Caspase4 | Exosomes | Specific | Exosomes | Specific | WPB | |
| Actin filament based process | 1 | |||||||||||
| Regulated exocytosis | 1 | 1 | 1 | 1 | ||||||||
| Hemostasis | 1 | |||||||||||
| Signaling by Receptor Tyrosine Kinases | 1 | |||||||||||
| Organelle localization | 1 | |||||||||||
| Cell morphogenesis involved in differentiation | 1 | |||||||||||
| Regulation of cell adhesion | 1 | 1 | ||||||||||
| Adaptive immune system | 1 | 1 | ||||||||||
| Membrane Trafficking | 1 | |||||||||||
| Cellular response to nitrogen compound | 1 | |||||||||||
| DNA conformation change | 1 | |||||||||||
| Cell substrate adherens junction assembly | 1 | |||||||||||
| Regulation of mRNA metabolic process | 1 | |||||||||||
| Detoxification of ROS | 1 | |||||||||||
| Orc1 removal from chromatin | 1 | |||||||||||
| Disease of signal transduction by growth factor receptors and second messengers | 1 | |||||||||||
| Stem cell differentiation | 1 | |||||||||||
| establishment of protein localization to endoplasmic reticulum | 1 | |||||||||||
| Cellular response to abiotic stimulus | 1 | |||||||||||
| actomyosin structure organization | 1 | |||||||||||
| Leukocyte degranulation | 1 | |||||||||||
| Endocytosis | 1 | |||||||||||
| RHO GTPase Effectors | 1 | |||||||||||
| Golgi vesicle transport | 1 | |||||||||||
| positive regulation of organelle organization | 1 | 1 | ||||||||||
| phagocytosis | 1 | |||||||||||
| Establishment of organelle localization | 1 | |||||||||||
| regulation of leukocyte activation | 1 | |||||||||||
| cytosolic transport | 1 | |||||||||||
| Table 1B | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Canonical | Canonical | Canonical | Canonical | Canonical | Caspase1 | Caspase1 | Caspase1 | Caspase4 | Caspase4 | Exosomes | Exosome | |
| Specific | Caspase1 | Caspase4 | Exosomes | WPB | Specific | Caspase4 | Exosomes | Specific | Exosomes | Specific | WPB | |
| NABA matrisome associated | 1 | 1 | ||||||||||
| extracellular structure organization | 1 | 1 | ||||||||||
| NABA core matrisome | 1 | |||||||||||
| humoral immune response | 1 | 1 | ||||||||||
| complement and coagulation cascades | 1 | |||||||||||
| NABA secreted factors | 1 | |||||||||||
| negative regulation of proteolysis | 1 | |||||||||||
| regulation of IGF transport and uptake by IGFBPs | 1 | |||||||||||
| response to wounding | 1 | |||||||||||
| Cell surface interactions at the vascular wall | 1 | |||||||||||
| Peptidyl tyrosine phosphorylation | 1 | |||||||||||
| negative regulation of supramolecular fiber organization | 1 | |||||||||||
| transcription of the HIV genome | 1 | |||||||||||
| oxidative phosphorylation | 1 | |||||||||||
| CDC5L complex | 1 | |||||||||||
| mRNA catabolic process | 1 | |||||||||||
| chaperone mediated protein transport | 1 | |||||||||||
| positive regulation of viral process | 1 | |||||||||||
| NABA ECM Glycoproteins | 1 | |||||||||||
| Cell-cell communication | 1 | |||||||||||
| Interconversion of nucleotide di-and triphosphates | 1 | |||||||||||
| organic cyclic compound catabolic process | 1 | |||||||||||
| carbon metabolism | 1 | |||||||||||
| protein folding | 1 | |||||||||||
| IL12 mediated signaling pathway | 1 | |||||||||||
| HIF-1 signaling pathway | 1 | |||||||||||
| pentose phosphate metabolism | 1 | |||||||||||
| establishment of protein localization to organelle | 1 | |||||||||||
| cellular response to oxidative stress | 1 | |||||||||||
| Table 1C | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Canonical | Canonical | Canonical | Canonical | Canonical | Caspase1 | Caspase1 | Caspase1 | Caspase4 | Caspase4 | Exosomes | Exosome | |
| Specific | Caspase1 | Caspase4 | Exosomes | WPB | Specific | Caspase4 | Exosomes | Specific | Exosomes | Specific | WPB | |
| Defective EXT2 causes exostoses 2 | 1 | |||||||||||
| cell substrate adhesion | 1 | |||||||||||
| VEGFA VEGFR2 signaling pathway | 1 | |||||||||||
| positive regulation of cytokine production | 1 | |||||||||||
| chemotaxis | 1 | 1 | ||||||||||
| small molecule catabolic process | 1 | |||||||||||
| aromatic compound catabolic process | 1 | |||||||||||
| cofactor metabolic process | 1 | |||||||||||
| oxidation reduction process | 1 | |||||||||||
| alpha amino acid metabolic process | 1 | |||||||||||
| cysteine and methionine metabolism | 1 | |||||||||||
| platelet degranulation | 1 | |||||||||||
| drug catabolic process | 1 | |||||||||||
| purine ribonucleoside metabolic process | 1 | |||||||||||
| myeloid leukocyte activation | 1 | |||||||||||
| positice regulation by host of viral process | 1 | |||||||||||
| regulation of endothelial cell proliferation | 1 | |||||||||||
| carbohydrate derivative catabolic process | 1 | |||||||||||
| intermembrane lipid transfer | 1 | |||||||||||
| fatty acid derivative biodynthetic process | 1 | |||||||||||
| metabolism of vitamins and cofactors | 1 | |||||||||||
| rhythmic process | 1 | |||||||||||
| response to virus | 1 | |||||||||||
| Cytokine-cytokine receptor interaction | 1 | |||||||||||
| defense response to other organism | 1 | |||||||||||
| GPCR ligand binding | 1 | |||||||||||
| PI3K-akt signaling pathway | 1 | |||||||||||
| glycoprotein metabolic process | 1 | |||||||||||
| skeletal system development | 1 | |||||||||||
| aminoglycan metabolic process | 1 | |||||||||||
| response to unfolded protein | 1 | |||||||||||
The signal pathways of the gene list from Figure 1B with 12 groups were analyzed by Metascape (https://metascape.org/gp/index.html#/main/step1).