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. 2022 Mar 21;14:16. doi: 10.1038/s41368-022-00166-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Reduction of commensal microbiota exacerbates periapical periodontitis-mediated MRONJ development. a Representative images of H&E staining at the site of extraction. b Quantification of empty lacunae number. c Quantification of necrotic bone presented as a percentage of the total bone area. P/E pulp exposed, P/U pulp unexposed. All quantified data represent mean ± SEM (n = 5–6). *P < 0.05; **P < 0.01; ns, not statistical significant. Scale bar: 50 μm