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. 2022 Mar 7;9:815916. doi: 10.3389/fcvm.2022.815916

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Copyright © 2022 Fa, Xiao, Chang, Ding, Yang, Wang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-194-5p was involved in DOX-induced cardiotoxicity in vivo. (A) The expression levels of miR-194-5p in mice heart tissue were detected after DOX treatment by qRT-PCR. (B) Adenovirus-harbored anta-miR-194-5p was injected into the mice 1 week before DOX treatment. The expression levels of PAK2, XBP1s and cleaved caspase-12 were detected by Western blot. Echocardiographic analysis of left ventricular cardiac function in mice, EF (C) and FS (D) results are shown. EF, ejection fraction; FS, fractional shortening. Apoptosis was measured by TUNEL assay (F) and apoptotic rates were analyzed (E). Green, TUNEL-positive nuclei; blue, DAPI (4,6-diamidino-2-phenylindole)-stained nuclei; scale bar, 500 μm. (G) Masson trichrome staining for collagen performed. scale bar, 200 μm. Anta-194, adenovirus-harbored miR-194-5p antagomir. N = 4, and the data were expressed as mean ± SD. ∧p < 0.05 vs. control. *p < 0.01 vs. control.