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. 2022 Mar 20;13:15. doi: 10.1007/s12672-022-00478-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — miR-93-5p is downregulated in ovarian cancer and predicate good outcome of patients. A The qPCR was applied to measure the expression of miR-93-5p in ovarian cancer tissues and normal ovary tissues (**P < 0.01). B The expression of miR-93-5p in ovarian tumor and normal health individual were extracted from the dbDEMC database (Experiment ID, EXP00625, **P < 0.01). C The qPCR was employed to measure the expression of CCND2 in ovarian cancer tissues and normal ovary tissues (*P < 0.05). D The Pearson analysis was performed to mRNA of CCND2 and miR-93-5p in tumor tissues. E The survival data and miR93-5p data were extracted from TCGA database and Kaplan–Meier Plotter analysis was performed (**P < 0.01). F Western blot were carried out to measure the CCND2 protein level in ovarian tumor tissues and normal ovary tissues (**P < 0.01). G IHC experiment was applied to detect the CCND2 in ovarian cancer tissue and normal ovary tissues, Scale bar = 150 μm (*P < 0.05)