TABLE 2.
Survival of mice infected intravenously with H. capsulatuma
| Study and inoculum (CFU) | Drug or treatment | Dose (mg/kg) | No. of days of survival
|
No. alive at day 30 | |
|---|---|---|---|---|---|
| Mean | SEM | ||||
| Study A (2.0 × 106) | Control | None | 15.2 | 2.9 | 2 |
| GM2 | 20 | 30b | 0 | 10 | |
| 10 | 28.4b | 2.6 | 9 | ||
| 5 | 29.1b | 1.9 | 9 | ||
| 2 | 30b | 0 | 10 | ||
| Amphotericin B | 1 | 30b | 0 | 10 | |
| 0.5 | 30b | 0 | 10 | ||
| Fluconazole | 10 | 23.2 | 4.0 | 7 | |
| 5 | 20.1 | 3.7 | 5 | ||
| Study B (108) | Control | None | 4.0 | 0.14 | 0 |
| GM3 | 5 | 6.7b | 0.9 | 0 | |
| 1.25 | 4.9 | 0.4 | 0 | ||
| 0.3 | 4.0 | 0.3 | 0 | ||
| 0.06 | 4.1 | 0.2 | 0 | ||
| Amphotericin B | 1.25 | 28.4b | 2.6 | 9 | |
| 0.3 | 4.8 | 0.2 | 0 | ||
| Fluconazole | 10 | 13.1b | 3.2 | 2 | |
a
Mice were treated from day 2 through 8 after infection, and their rates of survival were observed through day 30. Ten mice were in each treatment group.
b
P < 0.001 compared with the control group.