Figure 1.

Schematic diagram of the study design. In total, 217 post‐heart transplantation (HTx) patients were included in this study and divided into a derivation and a validation cohort by stratified random sampling. The derivation cohort was further divided into 5‐folds for cross‐validation when training the decision tree‐based machine learning model for the discrimination of cardiac allograft vasculopathy (CAV). The diagnostic performance of the final model was evaluated in the validation cohort and enrichment pathway analysis was applied.