FIGURE 3.

Regulatory signatures and functional modules can describe cell types by combinatorial codes. (A) The combination of regulatory signatures and functional modules describes cell types comprehensively. Transient factors, terminal selectors, and other activator and repressor mechanisms combined define a cell type’s ‘regulatory signature.’ (B) Combinatorial codes of regulatory factors direct effector genes to encode distinct functional modules in different cell types. TF, transcription factor; E.G., effector gene. Specific examples and references are provided in the text.