Table 1.
Characteristics of the patients at baseline
| Patients without coronary atherosclerosis (N = 572) | Patients with coronary atherosclerosis (N = 266) | P value | |
|---|---|---|---|
| Age (IQR), year | 61 (54–68) | 67 (61–73) | <0.0001 |
| Male gender, no. (%) | 402 (70) | 206 (77) | 0.03 |
| Body mass index (IQR), kg/m2 | 27.1 (23.9–30.5) | 26.5 (23.9–30.2) | 0.27 |
| NT‐proBNP (IQR), pg/mL | 1120 (533–2198) | 1424 (654–2742) | 0.02 |
| Estimated GFR (IQR), mL/min/1.73 m2 | 75 (60–94) | 73 (54–90) | 0.01 |
| QRS duration (IQR), ms | 144 (112–166) | 151 (120–167) | 0.04 |
| Left ventricular ejection fraction (IQR), % | 25 (20–30) | 25 (20–30) | 0.93 |
| Blood pressure (IQR), mmHg | |||
| Systolic | 121 (109–135) | 128 (114–142) | <0.001 |
| Diastolic | 73 (65–81) | 74 (66–83) | 0.38 |
| NYHA class, no. (%) | |||
| II | 326 (57) | 128 (48) | 0.02 |
| III | 238(42) | 136 (51) | |
| IV | 8 (1) | 2 (1) | |
| Coexisting conditions, no. (%) | |||
| Diabetes mellitus | 97 (17) | 79 (30) | <0.0001 |
| Hypertension | 146 (26) | 114 (43) | <0.001 |
| Permanent atrial fibrillation | 101 (18) | 63 (24) | 0.03 |
| Ever smoker | 453 (79) | 207 (78) | 0.65 |
| Means of exclusion of ischemic cause of heart failure, no. (%) | |||
| Myocardial scintigraphy | 2 (1) | 0 (0) | 0.34 |
| CT angiogram | 18 (3) | 2 (1) | 0.03 |
| Coronary angiography | 556 (97) | 264 (99) | 0.06 |
| Cause of heart failure, no. (%) | |||
| Idiopathic | 457 (80) | 191 (72) | <0.01 |
| Valvular | 20 (4) | 7 (3) | |
| Hypertension | 50 (9) | 41 (15) | |
| Other | 45 (8) | 27 (10) | |
| Medications, no. (%) | |||
| ACE‐inhibitor or ARB | 553 (97) | 255 (96) | 0.56 |
| Beta blocker | 525 (92) | 248 (93) | 0.47 |
| Aldosterone receptor antagonist | 325 (57) | 143 (54) | 0.41 |
| Amiodarone | 37 (6) | 13 (5) | 0.37 |
| Device therapy, no. (%) | |||
| Cardiac resynchronization therapy | 343 (60) | 164 (62) | 0.64 |
| Implantable cardioverter‐defibrillator | 276 (48) | 137 (52) | 0.38 |
ACE, angiotensin‐converting enzyme; ARB, angiotensin‐receptor blocker; CT, computed tomography; GFR, glomerular filtration rate; IQR, interquartile range; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; NYHA, New York Heart Association.