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. Author manuscript; available in PMC: 2022 Sep 8.
Published in final edited form as: Nat Struct Mol Biol. 2022 Mar 8;29(3):250–260. doi: 10.1038/s41594-022-00734-6

Fig. 4 |. 1B-open structure.

Fig. 4 |

Comparison of nsp13T-engaged (A) and 1B-open (B) structures. Two views are shown, a top view (top) and a side view (bottom). In the top view, the proteins are shown as molecular surfaces and color-coded according to the key at the bottom. In the side view, nsp13F is shown only as a dashed outline. The RNA is shown as atomic spheres. In the 1B-open structure (B), the nsp13T 1B domain is rotated open by 85° (represented by thick black arrows). The 5’-t-RNA emerging from the RdRp active site approaches the nsp13T RNA binding groove but does not enter it.

Also see Supplementary Video 2.