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. 2022 Mar 18;8(1):e001309. doi: 10.1136/bmjsem-2022-001309

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Design and flow chart of the Pro@Heart study. Endurance athletes are recruited from state and national sports programs from the age of 14 to 23 years. Baseline evaluation includes a clinical exam and intake of medical history, medication, supplements and exercise history, quantification of current training load through an electronic training diary, blood sampling, DEXA, resting 12-lead ECG, two- and three-dimensional resting TTE, cardiopulmonary exercise testing including 12-lead exercise ECG and maximal oxygen consumption measurement, CMR imaging at rest and during exercise and a 24-hour Holter monitoring. Follow-up consists of repeated testing at 2, 5, 10 and 20 years. CMR, cardiac magnetic resonance; DEXA, dual-energy x-ray absorptiometry; ECG, electrocardiogram; TTE, transthoracic echocardiograms.