TABLE 2.

Chemical structure, convulsant doses, molecular weights, and partition coefficient values of classic quinolone derivatives tested in ICR mice

Compound	R1	X	Y	R6	R7	CD50a (95% confidence interval)		Mol wt	clog Pb
						μg/g	nmol/g
CIN	C2H5	CH	N	OCH2O		35.1 (16.6–74.2)	133.8	262.22	0.259
CIP	c-C3H5	CH	CH	F		33.0 (19.8–54.9)	85.5	385.82	−0.805
NAL	C2H5	N	CH	H		55.8 (40.6–76.7)	240.3	232.24	0.909
NOR	C2H5	CH	CH	F		52.8 (33.7–76.6)	165.3	319.34	−0.630
OFX	OCHCH(CH3)CH2OCH		CH	F		28.9 (15.6–55.6)	80.0	361.37	−0.097
PFX	C2H5	CH	CH	F		22.5 (13.8–36.5)	48.3	465.49	0.225
RFX	OCHCH2CH2SCH		CH	F		39.2 (25.4–60.5)	98.03	399.87	−0.062

^aCalculated according to the method of Litchfield and Wilcoxon (23). 

^bCalculated by MedChem software release 3.5 (10).