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. 2022 Feb 28;18(5):2047–2059. doi: 10.7150/ijbs.69343

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HB-EGF induces mPTP opening and cytochrome C release via cAMP-PKA-JNK/ERK-Ca²⁺-FOXO1 pathway. A-C, Flow cytometry analysis evidenced that HB-EGF induced the opening of mPTP via cAMP-PKA-JNK/ERK-Ca²⁺-FOXO1 pathway. N = 3. D, Visualization of mPTP after treatment with rHB-EGF in the absence or presence of different inhibitor or 8-Br-cAMP. N = 3. E, HB-EGF induced the release of cytochrome C via cAMP-PKA-JNK/ERK-Ca²⁺-FOXO1 pathway. N = 3.