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. 2022 Feb 21;18(5):1878–1895. doi: 10.7150/ijbs.69934

Figure 2.

Figure 2

Downregulation of serum exosomal miR-197-3p associated with poor prognosis in radioresistant NPC patients. (A) The binding sites of HSPA5 and miR-197-3p were predicted. (B) MiR-197-3p was reduced 2.9 times for the radioresistant C666-1R vs the parent control C666-1 by analysis of miRNA microarray. (C) The expression of miR-197-3p was identified lower in the multiple radioresistant NPC lines compared to their control lines by qRT-PCR. (D, E) The expression of miR-197-3p was analyzed in serum of 27 healthy people and 40 NPC patients by qRT-PCR. (F) There was a correlation between HSPA5 and miR-197-3p in NPC samples. (G) The characteristics of exosomes were evaluated by transmission electron microscopy. (H, I) The expression of exosomal miR-197-3p was higher in healthy people (17 cases) than in NPC patients (25 cases).