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. 2022 Feb 7;18(5):1795–1812. doi: 10.7150/ijbs.68992

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Fig 5 — TBC1D14 suppressed cell migration and invasion through the inhibition of autophagy. (A-C) Wound healing assay was performed in TBC1D14-downregulated cells treated with DMSO, CQ (10μm/ml), or BA (100nm/ml). Representative images taken at 0h and 24h were shown on the left side. The mean percentage of wound healing area was shown on the right side. Scale bar: 100μm. (D-E) Migration and invasion ability of Fadu (D) and SCC15 (E) cells treated with DMSO, CQ (10μm/ml), or BA (100nm/ml) were analyzed by Transwell assay. Numbers of cells spreading through the transwell were counted by ImageJ software. Scale bar: 100μm. (F) Autophagy markers were detected in 16 cases of HNSCC primary-site tissues (8 cases with and 8 cases without lymph node metastasis) by western blotting analysis. * P-value <0.05, **0.01; ***<0.001. CQ: chloroquine. BA: bafilomycin A1. NC: negative control.