Table 1.

Phenotypes of SC mutant mouse models

SC Gene	Mutation type	Gender	Gonad size	Fertility	Reported meiotic defects	Reference
SYCP2	Partial deletion (exons 39-43)	Male	Small	Infertile	Synapsis failure, abnormal AEs, increased apoptosis	66
		Female	NA	Subfertile	Synapsis failure	66
SYCP3	Null	Male	Small	Infertile	Synapsis failure, zygotene arrest, increased apoptosis	102
		Female	NA	Subfertile	Failure in chiasma formation, aneuploidy	65
SYCP1	Null	Male	Small	Infertile	Synapsis failure, unrepaired DSBs, failure in CO formation, increased apoptosis	103
		Female	Small	Infertile	Increased apoptosis	103
SYCE1	Null	Male	Small	Infertile	Synapsis failure, unrepaired DSBs, increased apoptosis	88
		Female	Small	Infertile	Synapsis failure, unrepaired DSBs, increased apoptosis	88
SYCE2	Null	Male	Small	Infertile	Synapsis failure, unrepaired DSBs, increased apoptosis	104
		Female	Small	Infertile	Synapsis failure,unrepaired DSBs, increased apoptosis	104
SYCE3	Null	Male	Small	Infertile	Synapsis failure, unrepaired DSBs, increased apoptosis	105
		Female	Small	Infertile	Synapsis failure, unrepaired DSBs, increased apoptosis	105
SIX6OS1	Null	Male	Small	Infertile	Synapsis failure, unrepaired DSBs, increased apoptosis	31
		Female	No follicles	Infertile	NA	31
TEX12	Null	Male	NA	Infertile	Partial synapsis, unrepaired DSBs, failure in CO formation	106
		Female	Small	Infertile	Partial synapsis, unrepaired DSBs, failure in CO formation, increased apoptosis	106

Abbreviation: NA, not available; AE, axial element; CO, crossover.