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. 2022 Mar 21;13:122. doi: 10.1186/s13287-022-02796-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Viral load from day 1 (baseline) to 14 days after UC-MSC treatment. A–D Graphs representing relative viral quantification. Viral load was determined based on the relative expression of the viral gene RdRP in relation to the human POLR2B gene (normalizer). Viral gene expression gradually decreased in patient samples from day 1 (baseline) to day 14 (A, B). C, D After linearizing the data by the natural logarithm (ln (x)) and obtaining the linear equation, the angular coefficient of the viral load line (slope) and the coefficient of determination (R²) were established. C UC-MSC and D Placebo. The angular coefficient (slope) and R² of each patient are plotted in (E). Average of the angular coefficient of each group (F). Mean with SEM; Student's unpaired t test analysis. UC-MSC, umbilical cord mesenchymal stromal cell; ns, not significant