Table 2.

Estimated hazard ratios from Cox models for primary analysis and sensitivity analyses.

Type of analysis	HR (95% CI)
Primary analysis
Sex‐, age‐ and GP‐adjusted Fully adjusted modela	0.97 (0.94, 1.00) 0.92 (0.89, 0.95)
Sensitivity analyses
(i) No adjustment for BMI and smoking (ii) Single imputation (BMI/smoking) (iii) Multiple imputation (BMI/smoking) (iv) Additional adjustment for ethnicity (v) Single imputation (BMI/smoking/ethnicity) (vi) Delayed entry • By 1 year • By 2 years • By 3 years • By 4 years (vii) Truncated follow up (viii) a) Excluding those with pre‐study dementia (wider definition)b) Outcome definition via wider definition	0.93 (0.90, 0.96) 0.93 (0.90, 0.96) 0.93 (0.90, 0.96) 0.92 (0.88, 0.97) 0.93 (0.90, 0.96) 0.89 (0.86, 0.92) 0.87 (0.84, 0.90) 0.86 (0.83, 0.89) 0.86 (0.82, 0.90) 0.90 (0.87, 0.93) 0.92 (0.89, 0.94) 0.92 (0.89, 0.95)

^a Adjusted for sex, age, practice, year of study entry, frailty index, prior consultation rate, harmful alcohol use, BMI, smoking, chronic kidney disease, asthma, autoimmune disease, COPD, depression, hypertension, ischaemic heart disease, severe immunosuppression, liver disease, stroke, traumatic brain injury, herpes simplex, uncontrolled diabetes.