Table 2.
Meta‐analysis of blood lipid levels and risk of cognitive disorders.
| Comparison | TC | TG | LDL‐C | HDL‐C | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Pooled RR (95% CI) | I 2, % | p heterogeneity | N | Pooled RR (95% CI) | I 2, % | p heterogeneity | N | Pooled RR (95% CI) | I 2, % | p heterogeneity | N | Pooled RR (95% CI) | I 2, % | p heterogeneity | |
| All‐cause dementia | ||||||||||||||||
| Overall |
9 4 5 |
1.13 (1.04, 1.22) midlife:1.16 (1.05, 1.26) late‐life:1.05 (0.89, 1.22) |
22.4 0 46.9 |
0.244 0.652 0.110 |
2 | 1.27 (1.02, 1.53) | 38.8 | 0.201 | 6 | 1.08 (0.84, 1.32) | 59.7 | 0.03 | ||||
| Per 1‐mmol/L increment | 10 | 1.02 (0.99, 1.04) | 36.8 | 0.151 | ||||||||||||
| Per 3‐mmol/L increment | 10 | 1.07 (1.00, 1.12) | 37 | 0.15 | ||||||||||||
| Alzheimer‐type dementia | ||||||||||||||||
| Overall |
14 5 9 |
1.13 (1.06, 1.21) midlife: 1.14 (1.02, 1.27) late‐life: 1.13 (1.03, 1.22) |
4.7 31.4 0 |
0.4 0.212 0.456 |
4 | 1.10 (1.04, 1.15) | 27.8 | 0.245 | 6 | 1.05 (0.95, 1.15) | 40.7 | 0.134 | 10 | 1.00 (0.98, 1.01) | 49.7 | 0.037 |
| Per 1‐mmol/L increment | 10 | 1.03 (1.01, 1.05) | 37 | 0.094 | 3 | 1.04 (1.02, 1.06) | 6.96 | 0.433 | ||||||||
| Per 3‐mmol/L increment | 10 | 1.09 (1.02, 1.16) | 37 | 0.09 | 3 | 1.12 (1.05, 1.21) | 6.96 | 0.43 | ||||||||
| Vascular dementia | ||||||||||||||||
| Overall | 5 | 1.05 (0.87, 1.24) | 0 | 0.491 | 4 | 1.29 (0.85, 1.73) | 36.7 | 0.192 | 4 | 1.14 (0.88, 1.40) | 33.4 | 0.212 | 4 | 0.87 (0.45, 1.28) | 68.4 | 0.023 |
| CIND | ||||||||||||||||
| Overall | 4 | 0.74 (0.40, 1.07) | 71.1 | 0.016 | 1 | 0.8 (0.54, 1.04) | 3 | 0.79 (0.39, 1.19) | 72.9 | 0.025 | ||||||
TC, total cholesterol; TG, triglyceride; LDL‐C, low density lipoprotein cholesterol; HDL‐C, high density lipoprotein cholesterol; CIND, cognitive impairment without dementia; RR, relative risk; CI, confidence interval; N, number of studies.