TABLE 2.

Metabolite level distribution. Mean, standard deviation and coefficient of variation (CV) of each metabolite-to-creatine ratio, listed by algorithm and vendor as well as global summary values. Asterisks indicate significant differences (adjusted p < 0.01 = ** and adjusted p < 0.001 = *** or ^### or “’) in the mean (for the metabolite ratios) or the variance (for the CV) compared with the algorithm in the next row (LCModel vs. Osprey = ** or ***, Osprey vs. Tarquin = ^###, and Tarquin vs. LCModel = “’)

	[metabolite] / [tCr] (mean ± SD)
	tNAA	tCho	mI	Glx
GE
LCModel	1.48 ± 0.12	0.19 ± 0.02	0.85 ± 0.10	1.75 ± 0.25
Osprey	1.47 ± 0.10	0.18 ± 0.02	0.78 ± 0.09	1.42 ± 0.17
Tarquin	1.48 ± 0.11	0.22 ± 0.03	0.57 ± 0.07	2.05 ± 0.22
Philips
LCModel	1.38 ± 0.10	0.17 ± 0.02	0.81 ± 0.08	1.46 ± 0.14
Osprey	1.50 ± 0.12	0.18 ± 0.02	0.86 ± 0.10	1.34 ± 0.16
Tarquin	1.40 ± 0.12	0.16 ± 0.03	0.60 ± 0.09	1.78 ± 0.19
Siemens
LCModel	1.52 ± 0.19	0.19 ± 0.02	0.83 ± 0.09	1.65 ± 0.31
Osprey	1.54 ± 0.12	0.19 ± 0.02	0.89 ± 0.06	1.45 ± 0.14
Tarquin	1.50 ± 0.15	0.18 ± 0.03	0.65 ± 0.07	2.04 ± 0.19
global
LCModel	1.45 ± 0.15***	0.18 ± 0.02	0.83 ± 0.09	1.45 ± 0.15***
Osprey	1.50 ± 0.12###	0.18 ± 0.02	0.84 ± 0.09###	1.50 ± 0.12###
Tarquin	1.46 ± 0.14	0.18 ± 0.04	0.60 ± 0.0800’	1.93 ± 0.2400’
	CV (SD/mean)
	tNAA	tCho	mI	Glx
GE
LCModel	7.9%	12.9%	11.8%	14.2%
Osprey	6.9%	9.7%	11.1%	11.8%
Tarquin	7.5%	11.7%	11.2%	10.8%
Philips
LCModel	7.2%	10.6%	9.9%	9.7%
Osprey	8.0%	10.0%	11.8%	11.9%
Tarquin	8.8%	19.8%	15.2%	10.7%
Siemens
LCModel	12.4%	13.4%	10.8%	18.7%
Osprey	8.0%	11.1%	6.9%	10.0%
Tarquin	10.1%	14.3%	10.5%	9.3%
global
LCModel	10.0%	13.2%**	10.9%	16.4%***
Osprey	7.8%	10.4%###	11.7%###	11.8%###
Tarquin	9.3%	20.5%”‘	13.6%	12.3%