ISRCTN70438627.

Trial name or title	Early restorative crown therapy in children and adolescents with amelogenesis imperfecta (AI): a prospective double‐blind randomised controlled trial
Methods	Single centre double‐blind randomised controlled trial, split‐mouth design
Participants	Setting: Centre for Oral Rehabilitation, special care department for children and adolescents, Falun, Dalarna, Sweden Inclusion criteria: Children and adolescents with AI, 6 to 25 years of age, referred for oral rehabilitation Exclusion criteria: AI in combination with syndromes including mental retardation Randomised: 28 (15 boys and 13 girls). 12 to 23 years of age, all of Caucasian origin AI type was recorded as either hypoplastic type (14) or hypomineralised or hypomaturation type (14)
Interventions	Treatment with Procera crown therapy with Zirconia inner coping cemented with Rely X ARC cement or E‐MAX crowns with Zirconia inner coping cemented with Rely X ARC cement Follow‐up examinations: 1 month, 1 year and 2 years
Outcomes	Primary outcomes Quality of restorations after 1 month, 1 year and a 2‐year observation period according to Ryge & De Vinzenci (1983) Sensitivity, measured using the Visual Analogue Scale (VAS) score (0 = no pain, 10 = unbearable pain) at baseline, 1 month and 2 years Secondary outcomes Dental caries according to Amarante et al (1998) Gingivitis and periodontitis according to Nyman and Linde (2003) Apical status according to Örstavik (1986)
Starting date	1 January 2009
Contact information	Professor Goran Dahllöf Karolinska Institutet Department of Dental Medicine Division of Orthodontics and Pediatric Dentistry POB 4064 Huddinge SE‐14104 Sweden
Funding	Centre for Clinical Research, Public Dental Service Dalarna (Sweden)
Notes	1‐year results were published as an abstract in 2012