Figure 4. Indirect Lesion Effects as Evaluated Through Functional Lesion Connectivity.

(A) Lesion connectivity of the entire stroke sample. Lesions were positively connected to insular, opercular, and precentral and postcentral regions that were mostly part of the sensorimotor network. Negative lesion connectivity could be observed to posterior and medial frontal regions. (B) Significantly different lesion connectivity between patients without and with good reperfusion after endovascular thrombectomy. Generally, patients without good reperfusion experienced more pronounced positive lesion connectivity to right precentral and postcentral regions.