Table 2.

Effect of sex in humoral response following Pfizer-BioNTech (mRNA BNT162b2) vaccine administration.

Author	Country of origin	Sample size	Median age (range)	Measured immunoglobulin	% difference of means
Salvagno et al. [12]	Italy	925	Seropositive: ND y/o (30–56) Seronegative: ND y/o (31–57)	Anti-S-RBD IgG	D30 Among all participants, IgG titer is 13% higher in females vs. males Among baseline seronegative participants, IgG titer is 16% higher in females vs. males
Pellini et al. [13]	Italy	248	47 y/o (23–69)	Anti-S1/S2 IgG	D28 IgG titer is 37% higher in females vs. males
Jabal et al. [10]	Israel	514	57 y/o (30–60+)	Anti-N IgG	D21 IgG titer is 15% higher in females vs. males