Table 1.

Composite indices of inflammation.

Composite index	Definition
C1	[Neutrophil count ≥3.10* (×10³/μL)] or [NL Ratio ≥1.86**]
C2	[CRp >0.3 and <1.0 mg/dL] or [Fibrinogen ≥421** mg/dL]
C3	[Neutrophil count ≥3.10* (×10³/μL)] or [Fibrinogen ≥421** mg/dL]
C4	[NL Ratio ≥1.86**] or [Fibrinogen ≥421** mg/dL]
C5	[CRp >0.3 and <1.0 mg/dL] or [Neutrophil count ≥3.40** (×0³/μL)]

Composite indices development process: Division of the sample into two random halves and selection of one of them to construct the indices. Selection of the biomarkers that showed the highest correlations with prevalent PCS. Development of the indices by combining the upper ranges of their distributions. Selection of the indices that best-classified subjects according to PCS. Receiver-operating characteristic (ROC) analyses of the composite indices for validation.

Abbreviations. CRP, C-reactive protein; NL Ratio, Neutrophil/Lymphocyte Ratio.

*Values above the median; **Values in the third tertile.