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. 2021 Nov 19;101(4):473–482. doi: 10.1177/00220345211049403

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© International Association for Dental Research and American Association for Dental, Oral, and Craniofacial Research 2021

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Molar phenotype of Hedgehog pathway mutant mice. (A–D) E16.5 (A, B) and E17.5 (C, D) mice lacking Hedgehog coreceptor function: (A) wild type (WT); (B) Wnt1-Cre;Gas1^fl/fl (n = 3); (C) Cdon^–/–(n = 6); (D) Boc^–/– (n = 9). (E–J) E17.5 (E) Shh^GFP/+; (F) Shh^GFP/GFP (n = 8); (G) Gas1^+/–;Shh^GFP/+ (n = 8); (H) Gas1^+/–; Shh^GFP/GFP (n = 8); (I) Gas1^–/–;Shh^GFP/+ (n = 4); and (J) Gas1^–/–; Shh^GFP/GFP (n = 1). Loss of a single Gas1 allele does not affect molar phenotype in a Shh^GFP/+ background or alter molar fusion in a Shh^GFP/GFP background, while Gas1^–/–; Shh^GFP/+ mice have supernumerary teeth with reduced penetrance. Gas1^–/–;Shh^GFP/GFP embryos are early embryonic lethal, with a lack of mandibular molar development and only a poorly formed molar tooth identifiable in the anterior maxilla. Scale bar in J = 250 µm for (A) to (J).