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. Author manuscript; available in PMC: 2022 Jun 5.
Published in final edited form as: J Nucl Cardiol. 2021 Jan 8;29(3):1266–1276. doi: 10.1007/s12350-020-02479-5

Figure 4: Divergence of 14C-acetate uptake in MφIFNγ+LPS and MφIL4.

Figure 4:

Stimulation of murine macrophages with IFN-γ + LPS vs. IL-4 resulted in the divergence of 14C-acetate (A), characterized by a progressive decline by ~4 folds in MφIFNγ+LPS and a delayed ~64% increase in MφIL4. mRNA level of Slc16a1 (B) is increased in both MφIFNγ+LPS (3.9-fold) and MφIL4 (6.3-fold). Expression of Slc16a3 transcript (C) was also increased in MφIFNγ+LPS (6.1-fold); but the apparent overexpression of Slc16a3 in MφIL4 (3.3-fold) did not reach statistical significance (P = 0.14). The expression of Slc16a7 (D) was not significantly changed by the polarization state of macrophages (N = 7 for uptake assays and = 5 for gene expression assays).