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. Author manuscript; available in PMC: 2022 Jun 5.
Published in final edited form as: J Nucl Cardiol. 2021 Jan 8;29(3):1266–1276. doi: 10.1007/s12350-020-02479-5

Figure 5: Divergence of 14C-acetate uptake by human atherosclerotic plaques upon pro-inflammatory vs. inflammation-resolving stimulation.

Figure 5:

Induction of distinct polarization states in human carotid endarterectomy specimens is confirmed by quantification of M1 polarization markers (interleukin-1β (IL-1β) and nitric oxide synthase-2 (NOS2), panel A) vs. M2 polarization markers (CD163 and mannose receptor C-type 1 (MRC1), panel B). Quantitative autoradiography demonstrates that stimulation of plaques with IFN-γ + LPS leads to a significant decline in 14C-acetate uptake, while IL-4 stimulation increases 14C-acetate uptake (C–D). N = 3 endarterectomy specimens (2–3 tissue sections per each specimen quantified).