Table 3.

Binding affinity and cell growth inhibition of menin inhibitors 19–26^a

Compd.	R3	Binding affinity to menin (IC50 (nM))	Cell growth inhibition (IC50 (nM))
			MV4;11	MOLM13
19		2.7±0.5	2.3 ± 0.7	49.7 ± 7.2
20		2.8±0.3	112 ± 33	402 ± 246
21		3.8 ± 0.5	156 ± 30	594 ± 195
22		3.0 ± 0.4	77 ± 15	196 ± 44
23		3.7 ± 0.3	74 ± 24	188 ± 8
24 (M-1121)		2.7 ± 0.1	10.3 ± 2.9	51.5 ± 13.5
25		4.6 ± 1.7	436 ± 89	504 ± 42
26		4.2 ± 0.7	289 ± 82	630 ± 192

^aIC₅₀ values are average of three independent experiments.