. Author manuscript; available in PMC: 2022 Jul 22.

Published in final edited form as: J Med Chem. 2021 Jul 1;64(14):10333–10349. doi: 10.1021/acs.jmedchem.1c00789

Table 5.

Cell growth inhibitory activity of M-1121 in a panel of leukemia cell lines after 4 days of treatment determined by CellTiter-Glo^®

Cell line	MLL status	Disease Indication	Cell growth inhibition IC₅₀ (nM)

MV4;11	MLL/AF4	ALL	10
MOLM-13	MLL/AF9	AML	52
OCI-AML4	MLL-ENL	AML	3
SEM	MLL/AF4	ALL	51
KOPN8	MLL/ENL	ALL	110
RS4;11	MLL/AF4	ALL	1,000
HL-60	MLLwt	AML	>10,000
K562	MLLwt	CML	>10,000
MEG-1	MLLwt	CML	>10,000

AML: Acute Myeloid Leukemia; ALL: Acute Lymphocytic Leukemia; CML: Chronic Myeloid Leukemia.