Fig. 4.

The small molecule drugs marimastat and DMPS significantly increase the survival times of mice receiving lethal doses of D. typus venom. Data shown as Kaplan-Meier survival graphs for experimental animals (n = 5 per group, except prinomastat only group where n = 4) treated with either: 90 μg (4 x LD₅₀) of D. typus venom only (magenta), 118 μg of drug only (cyan) or 90 μg venom and 118 μg drug (black). Treatments were pre-incubated at 37 °C for 30 minutes prior to intravenous injection via the tail vein and animals were monitored for 6 hours. Data is shown for: A) DMPS, B) dimercaprol, C) marimastat, and D) prinomastat.