Table 2.
Effect of apolipoprotein E (ApoE) peptides from central protein domain in cell and animal models related to Alzheimer’s disease (AD) and differences in ApoE isoforms.
| Organism | Tissue | Fragment | Effect | Model | Note | Reference |
|---|---|---|---|---|---|---|
| Chicken | Embryonic sympathetic ganglia | 141-155 1 | Neurite degeneration | In vitro | N/A | Crutcher et al. 69 |
| Human | Interleukin-2-dependent T lymphocytes | 141-149 2 | Cytotoxicity | In vitro | N/A | Clay et al. 71 |
| Mouse | BV2-microglia cells | 133-149 3 | Inhibits the release of TNFα and NO through suppresses microglial activation | In vitro | N/A | Laskowitz et al. 184 |
| Mouse | Primary neuronal-glia cells | 133-149 3 | Suppresses neuronal cell death and calcium influx induced by NMDA | In vitro | N/A | Aono et al. 186 |
| Mouse | C57BL/6 J blastocysts | 133-149 3 | Following LPS administration suppresses inflammatory response | In vivo | N/A | Lynch et al. 185 |
| Rat | Hippocampal slices | 133-149 3 /141-148 4 | Acetylcholine-evoked responses in a dose-dependent manner are inhibited | Ex vivo | N/A | Klein and Yakel 187 |
| Frog | Oocytes | 133-1493/141-148 4 | Block α7 nAChRs disrupting nAChR signaling | Ex vivo | N/A | Gay et al.
188
Gay et al. 189 |
1
Gene ID: -
2
Gene ID: 348.
3
Gene ID: 25728.
4
Gene ID: 394678.
LPS, lipopolysaccharide; nAChR, nicotinic acetylcholine receptor; NMDA, N-methyl-d-aspartate; NO, nitric oxide; TNFα, tumor necrosis factor α.