Table 3.
Effect of apolipoprotein E (ApoE) C-terminal peptides in cell and animal models related to Alzheimer’s disease (AD) and differences in ApoE isoforms.
| Organism | Tissue | Fragment | Effect | Model | Note | Reference |
|---|---|---|---|---|---|---|
| Mouse | Neuro-2a neuroblastoma cells | 182-299
1
(13 kDa C-terminal) |
Inhibits Aβ fibril formation and favors formation and stabilization of Aβ hexameric species | In vitro | ApoE4 generates more 13 kDa fragment than ApoE2 or ApoE3 | Wellnitz et al. 190 |
| Human | Samples of frontal cortex | 224-299
2
(C-terminal) |
Greater accumulation of ApoE C-terminal fragment in the insoluble fraction of tissue homogenate in the severe AD group versus the control group | In vitro | ApoE4 could be a source of the C-terminal fragment accumulation | Wang and Turko 177 |
1
Gene ID: 11816.
2
Gene ID: 348.
Aβ, amyloid β.