Skip to main content
. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Org Lett. 2021 Oct 6;23(20):8013–8017. doi: 10.1021/acs.orglett.1c03029

Table 3.

Scope studies for hydrosilylation of non-terminal and 1,1-disubstituted epoxides.a

graphic file with name nihms-1785321-t0005.jpg
a

Reaction Conditions: 5 mol% Ni(OAc)2, 5 mol% L2 ligand, 10 mol% KO-t-Bu, 15 mol% BF3•OEt2, 1.1 eq silane at room temperature for 16h. Yields determined on purified products. In all cases, a single regioisomer was detected by 1H NMR on crude reaction mixtures. Hydrolysis Conditions: 15% NaOH (aq) and MeOH at room temperature for 8h.

b

Yield determined by 1H NMR versus mesitylene internal standard.

c

TBAF deprotection used for desilylation.