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. 2022 Mar 20;8:13. doi: 10.1186/s40813-022-00254-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Outline of the animal trial. Group I (10 piglets) was vaccinated on day 14 after weaning with the PRRSV-2 based Ingelvac® PRRS MLV (Boehringer-Ingelheim) and infected with the PRRSV-1 field isolate Cobbelsdorf on day 28 (i.e., 14 days post-vaccination). Group II (10 piglets) was vaccinated and challenged in the same manner, but additionally given 40 µg DON/kg body weight (“low dose”) on a daily basis on days 1–28. Group III (10 piglets) was treated analogously, but supplied with 80 µg DON/kg body weight (“high dose”). Animals in group IV (control group, 8 piglets) were mock-vaccinated on day 14, infected on day 28 and did not receive additional DON. Animals were monitored daily and euthanised at the indicated times; blood and organ samples were taken as displayed. For details, see text