Figure 1.

Shows a simulation performed using the Integrated Oscillator Model [IOM; (20)] of β-cell bursting in the steady state (e.g. in 11 mM glucose) to show the respective contributions of voltage-gated Ca²⁺ channels (I_Ca), voltage-dependent K⁺ channels (I_K), slow Ca²⁺-activated K⁺ channels (I_K(Ca)) and ATP-sensitive K⁺ channels (I_K(ATP)) to slow (A) versus fast (B) bursting electrical activity (V_m). Simulations were performed by Dr. Isabella Marinelli, to whom we are grateful.