TABLE 1.
pncA mutations in PZA-resistant M. tuberculosis isolates from northwestern Russia
| pncA nucleotide(s) | Mutation | Amino acid change | No. of isolates |
|---|---|---|---|
| −12a | T→G | Putative regulatory area mutation | 1 |
| −11 | A→G | Putative regulatory area mutation | 5 |
| 20 | T→G | Val7Gly | 1 |
| 22a | G→T | Asp8Tyr | 1 |
| 28a | C→A | Gln10Lys | 1 |
| 28a | C→T | Gln10Stop | 1 |
| 84a | C deletion | Reading frame change | 1 |
| 139a | A→T | Thr47Ser | 1 |
| 146a | A→T | Asp49Val | 1 |
| 146a | A→G | Asp49Gly | 1 |
| 196a | T→C | Ser66Pro | 1 |
| 286a | A→G | Lys96Glu | 1 |
| 304a | G→A | Ala102Thr | 1 |
| 305a | C→T | Ala102Val | 2 |
| 309a | C→G | Tyr103Stop | 1 |
| 347a | T→G | Leu116Arg | 1 |
| 374a | T→A | Val125Asp | 1 |
| 379–389a | 11-nucleotide deletion | Reading frame change | 1 |
| 398a | T→C | Ile133Thr | 1 |
| 422 | A→C | Gln141Pro | 2 |
| 460a | A→G | Arg154Gly | 1 |
| 478a | A→C | Thr160Pro | 2 |
| 481a | G→C | Ala161Pro | 2 |
a
New pncA mutation identified in this study. Five PZA-resistant isolates had wild-type pncA.