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. Author manuscript; available in PMC: 2022 Mar 21.
Published in final edited form as: Cell Rep. 2022 Feb 8;38(6):110322. doi: 10.1016/j.celrep.2022.110322

Figure 4. Exchange factors compete with R15 for binding to RAS.

Figure 4.

(A–C) Effects of impairing SOS binding either by serum starvation or D69N mutation on R15-RAS binding (A) KRAS(Q61L), (B) KRAS(G12D), and (C) HRAS(G12V) and HRAS(Q61L).

(D) Evaluation of A59G mutation on binding of R15 to various oncogenic RAS mutants.