Comparison 3. One or more hospitalisation events; no. of patients with events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 One or more hospitalisation event in 3 months of study	2	138	Odds Ratio (M‐H, Random, 95% CI)	0.47 [0.01, 36.46]
2 One or more hospitalisation event in 12 months of study	4	499	Odds Ratio (M‐H, Fixed, 95% CI)	0.21 [0.07, 0.61]
3 Subgroup ‐ secondary care; no. of patients with one or more hospitalisations in 12 months	2	126	Odds Ratio (M‐H, Fixed, 95% CI)	0.14 [0.04, 0.49]
4 Subgroup ‐ primary care; no. of patients with one or more hospitalisations in 12 months	1	134	Odds Ratio (M‐H, Fixed, 95% CI)	3.05 [0.12, 76.10]
5 No. of patients with one or more hospitalisation events in 12 months excluding Kokubu study	3	433	Odds Ratio (M‐H, Fixed, 95% CI)	0.30 [0.07, 1.25]