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SARS-CoV-2 inhibition in human Calu-3 cells by 1–3.
| Compound | EC50 (μM) a | CC50 (μM) a |
|---|---|---|
| Homofascaplysin A (1) | 1.1 ± 0.4 | ~5 |
| (+)-Aureol (2) | 4.0 ± 1.0 | >10 |
| Bromophycolide A (3) | 6.9 ± 2.0 | >10 |
| Remdesivir | 0.3 | >5 b |
| DMSO control | 8.3 ± 1.5 | >10 |
EC50 and CC50 were determined from dose response in Calu-3 cells. Averages from three independent experiments shown with standard error of the mean.
Literature precedent shows that CC50 for remdesivir was >40 μM against Calu-3 cells.43
