Figure 1. SARS-CoV-2 Omicron BA.1 and BA.2 evade human plasma neutralizing antibodies elicited by infection or primary vaccine series.

Plasma neutralizing antibody titers elicited by primary COVID-19 vaccination determined using SARS-CoV-2 spike VSV pseudotypes using VeroE6-TMPRSS2 as target cells. Individual points are representative geometric mean titers from two independent experiments consisting of two replicates each. Bars represent geometric means and error bars represent geometric standard deviations for each group. Statistical significance between groups of paired data was determined by Wilcoxon rank test and *p< 0.05, **p< 0.01, ***p< 0.001, ****p< 0.0001. Patient demographics are shown in Table S2. Normalized curves and fits are shown in Figure S1.