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[Preprint]. 2022 Mar 16:2022.03.15.484484. [Version 1] doi: 10.1101/2022.03.15.484484

Table 1:

Compounds Identified as ACE2 Binders and Inhibitors of SARS-CoV-2

ID Structure ACE2 binding, Kd (μM)a IC50 (μM)b Efficacy (%)c
1 graphic file with name nihpp-2022.03.15.484484v1-t0002.jpg 0.092 15.67 140.19
2 graphic file with name nihpp-2022.03.15.484484v1-t0003.jpg 0.382 17.58 124.61
3 graphic file with name nihpp-2022.03.15.484484v1-t0004.jpg 0.623 13.96 177.42
4 graphic file with name nihpp-2022.03.15.484484v1-t0005.jpg 0.727 19.72 100.73
5 graphic file with name nihpp-2022.03.15.484484v1-t0006.jpg 3.31 24.83 70.61

Notes:

a

ACE2-binding affinity (Kd) measured by MST;

b

IC50: half-maximal inhibitory concentration values obtained SARS-CoV-2 Fluc assay, measured in triplicate;

c

Efficacy: maximum inhibitory effect observed in SARS-CoV-2 Fluc assay.