Table 2.
Characteristics of people with RA and IBD not experiencing blood-test abnormalities over 2 years
| Characteristic | People with RA on methotrexate (prevalent and incident) not experiencing any NICE-specified blood-test abnormalities,an (%)b | All people with RA on methotrexate (prevalent and incident), n (%)b | People with IBD on azathioprine (prevalent and incident) not experiencing any of the NICE-specified blood-test abnormalities,a n (%)b | All people with IBD on azathioprine (prevalent and incident), n (%)b |
|---|---|---|---|---|
| Total | 1585 (52.8) | 3001 | 657 (56.5) | 1162 |
|
| ||||
| Age, years | ||||
| Median (range) | 63 (53–71) | 66 (56–75) | 43 (32–54) | 44 (32–58) |
| Mean (SD) | 61 (14) | 65 (14) | 44 (15) | 46 (17) |
|
| ||||
| Age group, years | ||||
| 18–39 | 113 (71.1) | 159 | 279 (57.9) | 482 |
| 40–59 | 547 (63.8) | 857 | 275 (65.0) | 423 |
| 60–79 | 805 (50.9) | 1583 | 100 (43.5) | 230 |
| ≥80 | 119 (29.6) | 402 | Suppressedc | 27| |
|
| ||||
| Sex | ||||
| Male | 495 (50.9) | 972 | 330 (58.1) | 568 |
| Female | 1089 (53.7) | 2029 | 329 (55.4) | 594 |
|
| ||||
| Socioeconomic status, IMD quintile | ||||
| 1 (most deprived) | 208 (52.7) | 395 | 85 (52.5) | 162 |
| 2 | 248 (52.9) | 469 | 102 (53.7) | 190 |
| 3 | 294 (52.4) | 561 | 131 (54.1) | 242 |
| 4 | 355 (53.2) | 667 | 173 (64.1) | 270 |
| 5 (least deprived) | 466 (52.4) | 889 | 157 (56.1) | 280 |
| Missing | 13 (65.0) | 20 | 11 (61.1) | 18 |
|
| ||||
| Long-term conditions at baseline | ||||
| CKD | 60 (14.9) | 403 | 10 (21.3) | 47 |
| CVDd | 148 (29.9) | 495 | 16 (23.9) | 67 |
| Heart failure | 26 (15.5) | 168 | Suppressedc | 22 |
| Diabetes | 142 (34.0) | 418 | 33 (33.3) | 99 |
| Hypertension | 524 (41.2) | 1271 | 70 (37.8) | 185 |
| Osteoarthritis | 429 (39.9) | 1076 | 42 (40.4) | 104 |
NICE-recommended test thresholds: white blood count ≥3.5×109/L; mean cell volume ≤105 fL; neutrophils ≥1.6×109/L; platelets ≥140×109/L; eosinophils ≤0.5×109/L; alanine aminotransferase ≤100 U/L; aspartate transaminase ≤100 U/L; albumin ≥30 g/L; and estimated glomerular filtration rate ≥60 ml/min/1.73 m2.
Unless otherwise stated.
Data not provided for confidentiality reasons, due to small numbers in this category.
Includes ischaemic heart disease, cerebrovascular disease, and peripheral vascular disease. CKD = chronic kidney disease. CVD = cardiovascular disease. IBD = inflammatory bowel disease. IMD = Index of Multiple Deprivation. NICE = National Institute for Health and Care Excellence. RA = rheumatoid arthritis. SD = standard deviation.